Exosomes are powerful nano-messengers that comprise nature’s cellular communication network. Our vision at Mantra Bio is that exosomes have tremendous potential to become a significant, next-generation therapeutic modality when engineered. Using state-of-the-art synthetic biology approaches, we can program therapeutic exosome vehicles (TEVs) to engage multiple disease pathways simultaneously with the right potency and selectivity for each target pathway.
Mantra Bio is the creator of REVEAL™, the world’s leading exosome engineering platform that combines AI/ML computational biology and synthetic biology to rapidly design and develop exosome therapeutics. REVEAL has accelerated the development of a diverse pipeline in areas such as ophthalmology and infectious diseases.
We identify novel targets using data science and machine-learning with our proprietary database of human exosome-to-cell-to-tissue OMICs data.
We leverage an advanced exosome engineering platform to display multi-specific, multi-valent, and multi-modal proteins on the exosome surface to target multiple disease pathways simultaneously.
We rapidly screen TEV candidates through cell-based assays and in vivo animal models to optimize selectivity, potency, and efficacy.