Exosomes are powerful nano-messengers that comprise nature’s cellular communication network. After decades of scientific discovery, exosomes are being harnessed to form a new class of biologics, exosome therapeutics, enabling unprecedented targeted delivery of therapeutic agents. Importantly, exosome therapeutics have been shown to be safe in many human trials.
Mantra Bio is the creator of REVEAL™, an exosome engineering platform combining computational biology and lab automation to generate targeted exosome vehicles (TEVs) for a broad set of therapeutic areas.
We identify novel targets using data science and machine-learning with our proprietary database of human exosome-to-cell-to-tissue OMICs data.
We use advanced exosome engineering methods to display targeting proteins on the exosome surface for tissue specificity and to load TEVs with therapeutic agents such as proteins, nucleic acids, and small molecules.
We rapidly screen TEV candidates through cell-based assays and in vivo animal models to measure selectivity and efficacy.